Welcome to the Laboratory of Andrew Y. Koh, M.D. in the Departments of Pediatrics (Hematology/Oncology and Infectious Diseases) and Microbiology at the University of Texas Southwestern Medical Center.
We are broadly interested in understanding how resident intestinal microorganisms (particularly bacteria and fungi and collectively referred to as the gut microbiome) influence the immune responses of human cancer and stem cell transplant patients in a wide variety of diseases: development of gut-derived microbial infections, autoimmune complications (such graft-versus-host disease), and modulating host immune-mediated anti-tumor activity.
Our projects generally involve a mix of experimental approaches, ranging from in vitro model systems, to animal models, to advanced molecular biology and immunology techniques, next-generation sequencing approaches, and translational work with human patients. Recent work involves using multiomic approaches (metagenomic shotgun sequencing, shotgun metabolomics, bulk cytokine profiling, single immune cell cytokine profiling, and proteomics) to identify microbial taxa and effectors (metabolites, proteins, cytokines) that drive phenotypes observed in both preclinical models and human patients.
Please explore our website to find out more about the lab’s ongoing research and the people doing the work.
Andrew Y. Koh, MD