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Publications

Featured Publications

  • Fan D, Coughlin LA, Neubauer MM, Kim J, Kim M, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY. Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Nature Medicine 2015 Jul; 21(7):808-14. PMID:26053625. Abstract and Full Text.

  • Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY. Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. PLoS Pathogens 2015 Aug 27; 11(8):e1005129. PMID: 26313907. Abstract and Full Text.

  • Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani M, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY. Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients. Biology of Blood and Marrow Transplantation. 2017 May; 23(5):820-829: PMID: 28192251. Abstract and Full Text.

  • Frankel AE, Coughlin LA, Kim J,  Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text. 

  • Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675.  Abstract and Full Text.

  • Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. PMID: 38359828; Abstract and Full Text.

Koh Lab Publications

  • Saini S, Sabaeifard P, Coughlin L, Poulides N, Gan S, Zhan X, Dang M, Koh A.Y. and Zia A. (2025), Identifying Microbiota and Immune Host Factors Associated With Bleeding Risk in Children With Immune Thrombocytopenia. Am J Hematol. https://doi.org/10.1002/ajh.27669. PMID: 40110651 Abstract and Full Text.

  • Ebigbo N, Long A, Do P, Coughlin L, Poulides N, Jewell T, Gan S, Zhan X, Koh AY. Optimizing Precision Probiotics for Mitigating Graft-Versus-Host Disease. Microorganisms. 2025 Mar; 13(4):706. https://doi.org/10.3390/microorganisms13040706. Abstract and Full Text.

  • Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. PMID: 38359828; Abstract and Full Text.

  • Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675.  Abstract and Full Text.

  • Mishra AA, Koh AY. The microbial and host factors that govern Candida gastrointestinal colonization and dissemination. Curr Opin Microbiol. 2021 Oct;63:29-35. doi: 10.1016/j.mib.2021.05.012. Epub 2021 Jun 7.PMID: 34111679 Abstract and Full Text.

  • Bui A, Choi Y, Frankel AE, Koh AY. Unbiased Microbiome and Metabolomic Profiling of Fecal Samples from Patients with Melanoma. Methods Mol Biol. 2021;2265:461-474. doi: 10.1007/978-1-0716-1205-7_33. PMID: 33704734 Abstract and Full Text.

  • Chong PP, Koh AY. The gut microbiota in transplant patients. Blood Rev. 2020 Jan;39:100614. doi: 10.1016/j.blre.2019.100614. Epub 2019 Aug 29.PMID: 31492463 Abstract and Full Text.

  • Frankel AE, Coughlin LA, Kim J,  Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text. 

  • Mishra AA, Koh AY. Adaptation of Candida albicans during gastrointestinal tract colonization. Curr Clin Microbiol Rep. 2018 Sep;5(3):165-172. doi: 10.1007/s40588-018-0096-8. Epub 2018 Jun 16.PMID: 30560045  Abstract and Full Text.

  • Simms-Waldrip TR, Koh AY. Food for Gut: Microbiota Fuels Immune Reconstitution after BMT. Cell Host Microbe. 2018 Apr 11;23(4):423-424. doi: 10.1016/j.chom.2018.03.015.PMID: 29649435 Abstract and Full Text.

Publications from AYK postdoctoral work, Harvard Medical School (2002-2008)

  • Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB. Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PLoS ONE, 2010 Dec 10; 5(12): e15131. PMID: 21170272. Abstract and Text

  • Kamei A*, Koh AY*, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of Acquisition of Pseudomonas aeruginosa Gastrointestinal Mucosal Colonization and Horizontal Transmission in a Murine Model. Journal of Infectious Diseases. 2010 Jan; 201(1):71-80. PMID: 19938976 * Both authors contributed equally to this work. Abstract and Full Text

  • Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB. Inescapable need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia. Infection and Immunity.   2009 Dec; 77(12):5300-5310. PMID: 19805527. Abstract and Full Text

  • van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PO, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Hoiby N, Givskov M, Bjarnsholt T. Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. Acta Pathologica, Microbiologica et Immunologica Scandinavica 2009 Jul; 117:537-46. PMID:19594494. Abstract and Full Text

  • Koh AY, Priebe GP, Pier GB. Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia.  Infection and Immunity 2005 Apr ; 73(4):2262-2272. PMID: 15784570. Abstract and Full Text

Publications from AYK residency, Harvard Medical School (1996-2002)

  • Koh AY, Pizzo PA. Empirical Oral Antibiotic Therapy for Low Risk Febrile Cancer Patients with Neutropenia.  Cancer Investigation  2002; 20(3): 420-433. PMID: 12025236. Abstract

  • Koh AY, Bernstein H.  Neonatal jaundice, animal-induced injuries, and immunizations.  Curr Opn Pediatr 2000; 12:413-425. PMID: 10943826. Abstract

  • Pizzo C, Mansbach J, Koh A, Tunnessen WW.  Pediatric Puzzler: new seizures in a 6-year old: expanding horizons.  Contemporary Pediatrics 1999; 16(8):25-33.