Featured Publications
Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani M, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY. Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients. Biology of Blood and Marrow Transplantation. 2017 May; 23(5):820-829: PMID: 28192251. Abstract and Full Text.
Frankel AE, Coughlin LA, Kim J, Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text.
Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675. Abstract and Full Text.
Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. PMID: 38359828; Abstract and Full Text.
Koh Lab Publications
Saini S, Sabaeifard P, Coughlin L, Poulides N, Gan S, Zhan X, Dang M, Koh A.Y. and Zia A. (2025), Identifying Microbiota and Immune Host Factors Associated With Bleeding Risk in Children With Immune Thrombocytopenia. Am J Hematol. https://doi.org/10.1002/ajh.27669. PMID: 40110651 Abstract and Full Text.
Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. PMID: 38359828; Abstract and Full Text.
Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675. Abstract and Full Text.
Frankel AE, Coughlin LA, Kim J, Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text.
Publications from AYK postdoctoral work, Harvard Medical School (2002-2008)
Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB. Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PLoS ONE, 2010 Dec 10; 5(12): e15131. PMID: 21170272. Abstract and Text
Kamei A*, Koh AY*, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of Acquisition of Pseudomonas aeruginosa Gastrointestinal Mucosal Colonization and Horizontal Transmission in a Murine Model. Journal of Infectious Diseases. 2010 Jan; 201(1):71-80. PMID: 19938976 * Both authors contributed equally to this work. Abstract and Full Text
van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PO, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Hoiby N, Givskov M, Bjarnsholt T. Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. Acta Pathologica, Microbiologica et Immunologica Scandinavica 2009 Jul; 117:537-46. PMID:19594494. Abstract and Full Text
Publications from AYK residency, Harvard Medical School (1996-2002)
Koh AY, Pizzo PA. Empirical Oral Antibiotic Therapy for Low Risk Febrile Cancer Patients with Neutropenia. Cancer Investigation 2002; 20(3): 420-433. PMID: 12025236. Abstract
Koh AY, Bernstein H. Neonatal jaundice, animal-induced injuries, and immunizations. Curr Opn Pediatr 2000; 12:413-425. PMID: 10943826. Abstract
Pizzo C, Mansbach J, Koh A, Tunnessen WW. Pediatric Puzzler: new seizures in a 6-year old: expanding horizons. Contemporary Pediatrics 1999; 16(8):25-33.