Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity

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Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675.  Abstract and Full Text

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.

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Frankel AE, Coughlin LA, Kim J,  Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text. 

Potential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant Patients.

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Koh AY. Potential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant Patients. Clinical Chemistry. 2017 Jul 18.  Abstract and Full Text

The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection.

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Koh AY.  The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection. PLoS Pathogens 2017 Jun 29; 13(6):e1006342. PMID: 28662165.   There is no Abstract link.  Full Text

Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients.

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Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani M, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY. Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients. Biology of Blood and Marrow Transplantation. 2017 May; 23(5):820-829: PMID: 28192251. Abstract and Full Text

Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies.

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Kim J, Kim M, Koh AY, Xie Y, Zhan X. FMAP: Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies. BMC Bioinformatics. 2016 Oct10; 17(1):420. PMID:27724866. Abstract and Full Text

Identifying host immune effectors critical for protection against Candida albicans infections.

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Koh AY. Identifying host immune effectors critical for protection against Candida albicans infections. Virulence 2016 Oct 2; 7(7):745-7. PMID: 27336198. Abstract and Full Text

Severe gut microbiota dysbiosis is associated with poor growth in patients with short bowel syndrome.

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Piper HG, Fan D, Coughlin LA, Ho EX, McDaniel MM, Channabasappa N, Kim J, Kim M, Zhan X, Xie Y, Koh AY. Severe gut microbiota dysbiosis is associated with poor growth in patients with short bowel syndrome. J Parenter Enteral Nutr. 2016 Jul 12. PMID:27406942. Abstract and Full Text

The complexities of bacterial-fungal interactions in the mammalian gastrointestinal tract.

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Lopez-Medina E, Koh AY. The complexities of bacterial-fungal interactions in the mammalian gastrointestinal tract. Microbial Cell. 2016 Mar 16; 3(5):191-195. PMID:28357354. Abstract and Full Text

Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis.

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Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY. Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. PLoS Pathogens 2015 Aug 27; 11(8):e1005129. PMID: 26313907. Abstract and Full Text