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Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.

Frankel AE, Coughlin LA, Kim J,  Froelich TW, Xie Y, Frenkel EP, Koh AY. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct 19. Abstract and Full Text

Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients.

Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani M, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY. Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of GVHD in pediatric stem cell transplant patients. Biology of Blood and Marrow Transplantation. 2017 May; 23(5):820-829: PMID: 28192251. Abstract and Full Text

Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis.

Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY. Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. PLoS Pathogens 2015 Aug 27; 11(8):e1005129. PMID: 26313907. Abstract and Full Text

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.

Fan D, Coughlin LA, Neubauer MM, Kim J, Kim M, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY. Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Nature Medicine 2015 Jul; 21(7):808-14. PMID:26053625. Abstract and Full Text

Mucosal damage and neutropenia are required for Candida albicans dissemination.

Koh AY, Köhler JR, Coggshall KT, Van Rooijen N, Pier GB. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathogens 2008; 4(2):e35 PMID:18282097. Abstract and Full Text